The Balanced Body Center

Immunotherapy Program for Breast Cancer

Introduction to Breast Cancer


Breast cancer strikes more women throughout the world than any other type of cancer except
skin cancer, and breast cancer incidence rates were up to 1 in 8 women as of 2008. Based on
scientific evidence, breast cancer is clearly a disease with many contributing risk factors. It is
important to recognize the multiple and often interacting factors that influence the risk
components. The cause of breast cancer is a complex web including an individualís genetic
material, what they consume, their activity level, lifestyle, reproductive history, and hormone
profile as well as how much exposure they have had to radiation, chemical carcinogens, and
synthetic chemicals. There are also different types of breast cancer, each with its own unique
risks and best treatment options. The Balanced Body Center offers a comprehensive approach
to finding the contributing factors of an individualís breast cancer. We are uniquely positioned to
help in the fight to overcome breast cancer with integrative and natural protocols.


Understanding Breast Cancer


1. Sign and Symptoms:
* Painful Lump
* Nipple Discharge
* Redness of Breast
* Dimpling of the Skin
* Fatigue
* Breast or Chest Pain

2. Risk Factors:
* BRCA Gene Mutation (10% of cases) associated with 40-85% lifetime risk
* Began menstruating at an early age
* Higher Bone Mineral Density (menopausal women)
* Oral Contraceptive Pill and Hormone Replacement Therapy
* Alcohol Use
* Consumption: Obesity, High Starch Intake, Low Fiber Intake, Low Vegetable Intake
* Sedentary Lifestyle
* Chemical Exposure: Pesticides, PCBís, DDTís, Dioxins, Benzenes
* Cigarette Smoke
* Melanocyte Nevi (moles): Premenopausal women with 15+ nevi greater than 3 mm on
one arm are 35% more likely to be diagnosed with breast cancer than women who have
no nevi (not a causal relationship, but likely a shared origin).

3. Alternative/Adjunct Diagnostic Tool:
* Thermography
* Ultrasound


4. Types of Breast Cancer:
* Luminal A ñ Estrogen Receptor Positive
* Luminal B ñ Estrogen Receptor Positive
* HER2 Positive ñ Estrogen Receptor Positive or Negative
* Basal-Like Cancer ñ Triple Negative Cancer

5. Most Important Prognostic Markers:
* Tumor Size
* Presence of Malignant Disease in Regional Lymph Nodes
The risk of dying from breast cancer increases with the number of positive nodes. Fairly
consistently, each additional diseased node adds a 6% risk of mortality.
6. Two Compartments Regarding Cancers:
* The first compartment is the tumor itself and all that goes wrong in a cancer cell.
* The second compartment is the body itself. The terrain in which the tumor is present
affects the malignancy of the tumor to a large extent with co-influence and co-
adaptation.



The Balanced Body Center Approach to Breast Cancer


Diagnostic Biomarker Tests
1. Blood Chemistry:
Complete blood panels are necessary to discover the terrain in which the tumor lives, but some
of the prognostic markers are highlighted below:
* Vitamin D is a very important bio marker to look at for breast cancer. Individuals with
insufficient vitamin D levels at diagnosis tend to have more aggressive cancers as
opposed to those with higher vitamin D levels. People who have adequate vitamin D
levels also have a lower risk of metastasis.
* Circulating Tumor Cells are a good measure of the benefit of treatment if measured
before and after treatment.
* Genetic Polymorphisms, specifically COMPT, present in the blood show that these
individuals are not able to appropriately metabolize their estrogens, which leave the
estrogens in a highly mutagenic (quinones).
* Insulin Growth Factor-1 in the world of healthy longevity and body-building can be a
good thing, but it is detrimental in the world of cancer. IGF-1 is now recognized as
responsible for a third of all breast cancer growth. An individual with IGF-1 needs a
lower glycemic eating program as well as supplements and herbs that help the
pancreas balance blood sugar levels.
* C-peptide is a molecule made by the pancreas every time an insulin molecule is
produced. Therefore, it is a clear measure of endogenous insulin production. C-
peptide is associated with an approximately 50% risk increase of invasive breast
cancer. Every 1 ng/ml increased C-peptide is associated with a 35% increase of
death from breast cancer. Once again, we look at sugar lowering strategies and
pancreatic help for this individual.
* Galectin-3 molecules are ìstickyî little particles produced by cancer cells to allow
them to metastasize. They are a good marker for the metastasis potential. Galectin-
3 indicates the need for modified citrus pectin at 15g/day as well as immune
enhancement with substances like beta-glucan, active hexose correlated compounds
(found in certain edible mushrooms) and melatonin.

2. Thyroid Testing:
* The thyroid should be assessed since there is an increased prevalence of
autoimmune thyroid disease in patients with breast cancer.
* Breast tissue competes with the thyroid for adequate iodine, and iodine deficient
breast tissue is susceptible to lipid oxidation, a contributor to many diseases
including cancer. Also, without adequate iodine, the breast tissue is subject to
estrogenic stimulation. Because the breast tissue and the thyroid cannot function
optimally without proper levels of iodine, thyroid testing is essential.

3. Inflammation Biomarker Panels:
Cancer is known to proliferate in chronically inflamed individuals, and there are several
biomarkers that can be assessed to determine the level of inflammation, the cause, and
how it can be treated.

* High Sensitive C-Reactive Protein
* Ferritin
* Fibrinogen
* Interleukin-6 (due to the correlation between vascular endothelial growth
factor)

4. Gastrointestinal Function Testing:
Improper digestive system function is a contributor to systemic inflammation and toxic
overload.
* Food Sensitivity
* GI Permeability
* Systemic Yeast
* Acid / Alkaline Balance

5. Telomere Testing:
* Telomeres are the protective caps on the end of chromosomes. When they are
abnormally short they are unstable and more likely to gain mutations and become
malignant. People with cancer who have shorter telomeres also have an increased risk
of dying from cancer. Telomeres can be lengthened with an increased level of
telomerase which is stimulated by flavonoids and lifestyle changes.


6. Heavy Metal Toxicity Testing:
* Scientific evidence indicates that long-term exposure to some metallic compounds
induces different forms of cancer, including breast cancer. Studies by scientists have
widely demonstrated that exposure to heavy metals shares several primary mechanisms
of toxicity, including the production of reactive oxygen species, reaction with intracellular
thiols, and competition with essential metals in biological systems.
* According to The Journal of Toxicology, lead was found to accelerate tumor growth
rates. The same researchers found evidence that lead and other metals also interact
with iodine, a vitally important essential trace element that most likely protects against
breast cancer development.
* Multiple reports show that metallic compounds function as estrogen disruptors and
underline the connection between the exposure to metals or metal compounds and
breast cancer risk.

7. pH Testing:
* Acidity is a well-known factor associated with cancer. Lower pH levels in the
extracellular space promote the invasive and metastatic potential of cancer cells.
* Acid-base imbalance has been shown to increase systemic processes that serve as
intermediary effectors of tumor promotion.

8. Hormone Testing:
Equilibrium, or homeostasis, of the endocrine system is imperative for proper immune up-
regulation and protection against breast cancer risk and proliferation.

* Science has discovered evidence supporting a link between high lifetime synthetic
estrogen exposure and increased breast cancer risk. New data suggests that
maternal exposure during pregnancy increases breast cancer risk among daughters
due to induced epigenetic modifications in the mammary gland and germ cells,
thereby causing breast cancer risk through inheritance for multiple generations.
* It has been proposed that exposure to psychological stress and stress-related
cortisol release may be associated with increased breast cancer risk. A study
showed that prolonged exposure to stress may facilitate tumor progression by
suppressing the removal of genetically altered mammary epithelial cells by cortisol.

9. Environmental toxicity testing
While the health concerns of our environmental changes are not fully understood, it is evident
that there are many everyday chemicals that are harmful to our health. Every day, we are
exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides,
packaged foods, household products, and environmental pollution. As we have become more
exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have
been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic
fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune
disorders, Parkinsonís disease, and Alzheimerís disease.
The Balanced Body Center offers the GPL-TOX test to evaluate for the presence of 172
different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene,
vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene
oxide, acrylonitrile, and more. This profile also includes Tiglylglycine (TG), a marker for
mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can be
caused by exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.






Natural Strategies


The individualís toxic load must be reduced to allow physiological systems to function at their
optimum level. We cannot fight cancer effectively if our body is in toxic overload.

1. Body Weight:
* Excessive weight or obesity is responsible for one of every five individuals diagnosed
with cancer in the United States.
* A BMI over 30 in premenopausal women with estrogen receptor positive tumors
increases their risk of dying from cancer by 34%.
* Also, being too underweight increases the chance for recurrence of breast cancer.

2. Whole Food Meal Plan:
* Most processed foods contain sugar and chemicals that are toxic to the body.
* Fat intake is not associated with breast cancer and higher total fat is associated with
lower risk of lethal breast cancer. Saturated fats are not associated with lethal breast
cancer risk. Fat does not play a role in causing advanced or aggressive breast
cancers.
* Meat consumption should be limited to natural sources such as grass-fed beef or
organic poultry that has not been injected with hormones or antibiotics.
* Individuals should consume plenty of vegetables and herbs/spices, choosing organic
when available and washing or peeling when organic is not available.

3. Exercise:
* Regular physical activity has conclusively shown a reduced risk of dying from all
causes and specifically from breast and colon cancer.
* Vigorous exercise has now been shown to reduce breast cancer risk more than
moderate exercise. Risk reduction is greater with less time spent on exercise if the
exercise is more vigorous.
* Women who engaged in 30 minutes of vigorous exercise, 5 days a week were
shown to reduce their risk of dying from breast cancer by 25% compared with
women who exercised less.
* Itís not too late ñ research shows that women who were not exercising before being
diagnosed with breast cancer and then started exercising had a 45% lower risk of
dying from breast cancer than those who never increased their activity.

4. Toxic Chemical Exposure:

* There are an estimated 80,000 synthetic chemicals used in the United States with
only 7% that have been fully tested for their impact on human health. Reading labels
and choosing chemical-free products is vitally important, especially if there has been
a cancer diagnosis.
* Cleaners that contain toxic chemicals can put an individual in toxic overload.
* Beauty products, lotions, shampoos, etc., may contain hormone-altering chemicals.
* Plastic and rubber products, carpets, etc. contain toxic chemicals.
* The list is exhaustive, but avoiding toxic chemicals is a priority.





5. Stress Reduction:

* Stress hormones bind to receptors on cancer cells and encourage proliferation.
* Emotional stress not handled appropriately can lead to a physiological cascade of
chemicals and hormones that are damaging to the body.
* The CDC reported in 2013 that stress was the underlying cause of 80% of disease in
America.
* Individuals who are chronically stressed have an increased risk of breast cancer or
any cancer for that matter.
* Women who lead highly stressful lives with no good stress management techniques
are at increased risk of progression, recurrence, and metastasis.
* Life changes may be necessary to overcome breast cancer.

6. Restorative Sleep:

* A study of Japanese women who slept less than six hours per night showed a 62%
increased risk of developing breast cancer compared to women who slept more than
7 hours.
* Current research is being done on night shift workers to determine the role of
decreased melatonin levels and increased risk of breast cancer.

7. Proper nutrient supplementation:

There are many supplements that are beneficial to individuals with breast cancer. The
recommendations are based on each personís need, diagnosis, stage of cancer, type of breast
cancer, and period of life. The Balanced Body Center is equipped to give individualized care.

* Cautions: Some multivitamins contain isolated beta-carotene, boron, and copper.
Isolated beta carotene is associated with increase mutations in DNA. It is ok to ingest
beta-carotene in whole food form. Boron elevates estradiol levels and should not be
taken by individuals with estrogen receptor positive cancers. Copper facilitates
angiogenesis which is not beneficial for those with cancer.
* Green tea blocks oncogene formation. It is effective in early stage breast cancer but
has no benefit in late stages. In a study, after only 30 days, women who took 40 mg
of ECGC (found in green tea) had lowered their level of KI67 (a marker to determine
proliferation of cancer cells). Another study showed that women who drank 8 or
more cups of green tea per day had a recurrence rate of only 16% while the group
drinking 4 or less cups per day had a recurrence rate of 24%
* Evidence suggests that the simultaneous administration of multiple phytochemicals
is more effective than each one alone. The combination, in physiological relevant
levels, resulted in a significant decrease in cellular proliferation, increased apoptosis,
and decreased migratory and invasive capacity of estrogen receptor positive breast
cancer cells. Curcumin, Genistein, Indol-3-Carbinol, Spirulina Platensis, combined
with Selenium, Resveratrol and Quercetin were administered in the study.
* Melatonin is one of the best studied natural substances in treating cancer. It has
been shown to double survival rates and the time before another recurrence in
individuals receiving chemotherapy and/or radiation. It also impacts longevity when
taken continually post treatment.